Bactericidal, fungicidal and virucidal
Ozone can destroy practically all kinds of bacteria, viruses, fungi, and protozoa. The use of therapeutic ozone concentration provides bactericidal effect which indirectly activates the non-specific defense system (phagocytosis activation, enhanced synthesis of cytokines-interferons, interleukin tumor necrotic factor) as well as components of cellular and humoral immunity. There have been reported evidences of partial oxidation of virus receptors that makes them incapable to virus binding.
This effect is revealed in ozone capacity to oxidize the compounds containing double bonds, the arachidonic acid and its derivatives – prostaglandins, in particular. These biologically active substances participate in the development and sustaining the inflammatory process. Besides, ozone regulate metabolic reactions in tissues at the place of inflammations and resolves pH.
This effect is provided by oxidation of the product of albuminolysis, the so-called algopeptides. They act on the nerve endings in damaged tissue and determine the intensity of pain response.
This effect is revealed in correction and activation of metabolic processes in the hepatic and renal tissues, thus ensuring their main function of neutralization and evacuation of the toxic compounds from the organs.
Activation of oxygen-dependent processes
Ozone doses, however low they are, cause the increase in the content of free and dissolved blood oxygen with rapid intensification of enzymes that catalyze aerobic oxidation of carbohydrates, lipids, and proteins with formation of ATP energy substrate. Of great importance is the mitochondria activation of H-ATP-ase responsible for conjugation of respiratory processes and oxidative phosphorylation resulting in ATP synthesis.
Optimization of pro and anti oxidant system
This is regarded as one of the main effects of systemic ozone therapy which is realized through its influence on cellular membranes and brining to balance the levels of lipid peroxidation products and of antioxidant defense system.
Ozone haemostatic effect
This effect depends on the dose. High concentration administered for external use cause evident hyper coagulation effect while parenteral administration of low concentrations is characterized by the decrease in thrombocytic and coagulative levels of hemostasis and increase in fibrinolytic activity.
Ozone immune-modulating effect
This effect is based on interaction with lipid structures of cellular membranes and depends on the chosen dose.